Precision Gene Therapy for Hair Cell Regeneration

Time: 11:45 am
day: Day Two


  • We are engineering gene therapies to convert supporting cells, the cells adjacent to hair cells, into both cochlear and vestibular hair cells in order to restore hearing and balance function through selective expression of reprogramming factors that control cell fate
  • We have observed that selective expression of reprogramming factors via proprietary support cell selective promoters resulted in regeneration of vestibular hair cells in vivo
  • We are evaluating whether a single AAV vector expressing a combination of reprogramming factors may further enhance maturation of hair cell types