Leveraging a Systemic Drug Delivery to Preserve Hearing During Aminoglycoside Therapy
Time: 12:00 pm
day: Day One 1
Details:
- ORC-13661 adjunctive therapy to prevent aminoglycoside-induced ototoxicity in patients with non-mycobacterial tuberculosis (NTM)
- Identification of the optimal patient population
- Dose selection in the absence of target engagement optimizes efficacy while minimizing off-target effects
- Treatment duration to optimize signal-to-noise while ensuring safety
- Primary and secondary endpoint selection
