Leveraging a Systemic Drug Delivery to Preserve Hearing During Aminoglycoside Therapy

Time: 12:00 pm
day: Day One 1


  • ORC-13661 adjunctive therapy to prevent aminoglycoside-induced ototoxicity in patients with non-mycobacterial tuberculosis (NTM)
  • Identification of the optimal patient population
  • Dose selection in the absence of target engagement optimizes efficacy while minimizing off-target effects
  • Treatment duration to optimize signal-to-noise while ensuring safety
  • Primary and secondary endpoint selection